The principal cytochrome P450 isoenzyme involved seems to become CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Somewhere around 85% of the oral dose seems inside the urine in 24 hrs of administration, most because the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity information.No